The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Aug. 06, 2013
Trustees of Boston University, Boston, MA (US);
Universita Di Perugia, Perugia, IT;
Emiliano Biasini, Newton, MA (US);
David A. Harris, Boston, MA (US);
Aaron Beeler, Cambridge, MA (US);
Brian R. Fluharty, Boston, MA (US);
Maria Letizia Barreca, Perugia, IT;
Nunzio Iraci, Perugia, IT;
Oscar Ingham, Boston, MA (US);
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
UNIVERSITA DI PERUGIA, Perugia, IT;
Abstract
The invention provides compositions and methods for treatment of neurodegenerative diseases or disorders, particularly neurodegenerative diseases and disorders associated with protein aggregation. The present invention is based on the discovery of binding regions on the surface of PrPc, referred to as PrPc Binding Domains (PBD). In particular, the inventors have identified six different binding regions on PrPc, referred to herein as PrP-binding domain-1 (PBD-1), PrP-binding domain-2 (PBD-2), PrP-binding domain-3 (PBD-3), PrP-binding domain-4 (PBD-4), PrP-binding domain-5 (PBD-5), and PrP-binding domain-6 (PBD-6), herein. The PBD-1 to PBD-6 are each defined by a cluster of amino acids located in the globular domain of the protein, e.g., in the C-terminal half of the protein (i.e., in residues 120-230). One embodiment uses residues 127-226.