The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
Jun. 30, 2016
Applicant:
Firmenich SA, Geneva, CH;
Inventors:
Michel Schalk, Geneva, CH;
Letizia Rocci, Geneva, CH;
Assignee:
Firmenich SA, Geneva, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 5/00 (2006.01); C12N 15/63 (2006.01); C12N 15/74 (2006.01); C12N 15/79 (2006.01); C12N 9/88 (2006.01); C12N 9/90 (2006.01); C12N 15/70 (2006.01);
U.S. Cl.
CPC ...
C12P 5/002 (2013.01); C12N 9/88 (2013.01); C12N 9/90 (2013.01); C12N 15/63 (2013.01); C12N 15/70 (2013.01); C12N 15/74 (2013.01); C12N 15/79 (2013.01); C12P 5/007 (2013.01); C12Y 402/03 (2013.01); C12Y 505/01012 (2013.01); C12Y 505/01014 (2013.01);
Abstract
Provided herein are methods of producing (+)-manool comprising: contacting geranylgeranyl diphosphate with an copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate wherein the CPP synthase comprises an amino acid sequence having at least 90%, 95%, 98%, 99% and 100% sequence identity to a polypeptide selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO:2; and contacting the CPP with a sclareol synthase enzyme to form (+)-manool.