The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
Sep. 05, 2017
Applicant:
Intrexon Actobiotics NV, Zwijnaarde, BE;
Inventors:
Erik Remaut, Vinderhoute, BE;
Dirk Iserentant, Wijgmaal, BE;
Assignee:
INTREXON ACTOBIOTICS NV, Zwijnaarde, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/74 (2006.01); C12N 1/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/746 (2013.01); C12N 1/04 (2013.01);
Abstract
strains with improved preservation characteristics, and improved acid and bile salt tolerance are disclosed. More specifically, astrain having a heterologous trehalose-6-phosphate synthase gene and/or a trehalose-6-phosphate phosphatase gene, results in an accumulation of trehalose in the cytoplasm and/or in the cytoplasmic membrane. Astrain, having an internal trehalose concentration of at least 10 mg per gram cells (w/w) is disclosed.