The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
Mar. 03, 2017
Applicant:
Vilnius University, Vilnius, LT;
Inventors:
Virginijus Siksnys, Vilnius, LT;
Migle Kazlauskiene, Vilnius, LT;
Gintautas Tamulaitis, Vilnius, LT;
Assignee:
VILNIUS UNIVERSITY, Vilnius, LT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 9/22 (2006.01); C07K 14/315 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); C07K 14/315 (2013.01); C12N 9/22 (2013.01); C12N 15/113 (2013.01); C12Y 301/27 (2013.01); C12N 2310/10 (2013.01); C12N 2310/20 (2017.05);
Abstract
A Type III-A CRISPR-Cas (StCsm) complex ofcomprising crRNA, Csm4, and Csm3 and use for cleavage of RNA bearing a nucleotide sequence complementary to the crRNA, in vitro or in vivo. Methods for site-specific cleavage/shredding of a target RNA molecule using an RNA-guided RNA endonuclease comprising a minimal complex of crRNA, Csm4, and Csm3, and methods of RNA knock-down and RNA knock-out are disclosed.