The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
Nov. 02, 2016
Zhejiang Huahai Pharmaceutical Co., Ltd, Linhai, CN;
Shanghai Syncores Technologies Inc. Ltd., Shanghai, CN;
Siyuan Li, Shanghai, CN;
Shaoxiao Gui, Shanghai, CN;
Jicheng Zhang, Shanghai, CN;
Luning Huang, Shanghai, CN;
Anping Tao, Shanghai, CN;
Hong Gu, Shanghai, CN;
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, Linhai, CN;
SHANGHAI SYNCORES TECHNOLOGIES INC. LTD., Shanghai, CN;
Abstract
The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, formula A, formula B, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C-Calkyl, and C-Calkoxy, and Ris C-Calkyl or C-Calkyl substituted by halogen. The method comprises: generating a compound having a structure as shown in Formula C and a compound having a structure as shown in Formula D by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, and sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C-Calkyl, and C-Calkoxy.