The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2019

Filed:

Jun. 20, 2018
Applicants:

Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;

Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;

Inventors:

Shanghai Yu, Shanghai, CN;

Fanglong Yang, Shanghai, CN;

Lei Chen, Shanghai, CN;

Jingjing Yan, Shanghai, CN;

Xiqian Zhang, Shanghai, CN;

Zhichao Xie, Shanghai, CN;

Lingxiang Chen, Shanghai, CN;

Mingxun He, Shanghai, CN;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4725 (2006.01); A61K 31/4741 (2006.01); C07D 491/056 (2006.01); A61K 31/4743 (2006.01); C07D 217/14 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 417/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 217/16 (2006.01); C07D 401/10 (2006.01); C07D 405/12 (2006.01); C07D 413/10 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/056 (2013.01); A61K 31/4741 (2013.01); A61K 31/4743 (2013.01); C07D 217/14 (2013.01); C07D 217/16 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 405/12 (2013.01); C07D 413/10 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01);
Abstract

The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention relates to the piperidine derivative as shown by general formula (I) and the preparation method thereof and a pharmaceutical composition containing the same, and the use thereof as an estrogen receptor modulator in the treatment of estrogen receptor mediated or dependent diseases or conditions, the diseases preferably being breast cancer. In the abstract, the definition of each substituent of the general formula (I) is the same as that in the description.


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