The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2019

Filed:

Mar. 24, 2015
Applicant:

Jiangsu Carefree Pharmaceutical Co., Ltd, Nanjing, CN;

Inventors:

Yinlin Qin, Nanjing, CN;

Mei Su, Nanjing, CN;

Shousheng Yan, Nanjing, CN;

Xianzhi Wu, Nanjing, CN;

Tao Chen, Nanjing, CN;

Jianhua Jiang, Nanjing, CN;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 487/04 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01);
Abstract

The invention relates to a 4-substituted pyrrolo[2,3-d]pyrimidine compound and the use thereof in preparing medications for treating JAK-targeted diseases such as rheumatoid, immune system diseases, and tumor. The 4-substituted pyrrolo[2,3-d]pyrimidine compound of the invention is as shown in chemical formula I. The activity experimental results of the invention show that the new compound has obvious effect and activity in inhibition of Janus kinases, JAK-STAT, cell proliferation of human lymphocytoma, and rheumatoid arthritis.


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