The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2019

Filed:

Sep. 10, 2014
Applicants:

Merck Sharp & Dohme Corp., North Wales, PA (US);

Lawrence Livermore National Security, Llc, Livermore, CA (US);

Inventors:

John Finn, Encinitas, CA (US);

Leslie William Tari, San Diego, CA (US);

Zhiyong Chen, San Diego, CA (US);

Junhu Zhang, San Diego, CA (US);

Douglas Phillipson, Del Mar, CA (US);

Suk Joong Lee, San Diego, CA (US);

Michael Trzoss, San Diego, CA (US);

Daniel Bensen, Carlsbad, CA (US);

Xiaoming Li, San Diego, CA (US);

Min Teng, San Diego, CA (US);

Voon Ong, San Diego, CA (US);

Allen John Borchardt, San Diego, CA (US);

Thanh To Lam, San Diego, CA (US);

Felice C. Lightstone, Fremont, CA (US);

Sergio E. Wong, Tracy, CA (US);

Toan B. Nguyen, Marlborough, CA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/00 (2006.01); A61K 31/505 (2006.01); C07D 487/04 (2006.01); C07D 491/16 (2006.01); C07F 9/6561 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 491/16 (2013.01); C07F 9/6561 (2013.01); A61K 31/519 (2013.01);
Abstract

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.


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