The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2019

Filed:

Jul. 22, 2016
Applicant:

Ono Pharmaceutical Co., Ltd., Osaka, JP;

Inventors:

Seiji Ogawa, Osaka, JP;

Toshihide Watanabe, Osaka, JP;

Isamu Sugimoto, Osaka, JP;

Kousuke Tani, Osaka, JP;

Kazumi Moriyuki, Osaka, JP;

Yoshikazu Goto, Osaka, JP;

Shinsaku Yamane, Osaka, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/04 (2006.01); C07D 407/04 (2006.01); C07D 409/04 (2006.01); C07D 417/14 (2006.01); A61K 31/352 (2006.01); A61K 31/381 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61P 27/06 (2006.01); A61P 27/10 (2006.01); A61P 27/12 (2006.01); A61P 27/02 (2006.01);
U.S. Cl.
CPC ...
C07D 417/04 (2013.01); A61K 31/352 (2013.01); A61K 31/381 (2013.01); A61K 31/427 (2013.01); A61K 31/428 (2013.01); A61P 27/02 (2018.01); A61P 27/06 (2018.01); A61P 27/10 (2018.01); A61P 27/12 (2018.01); C07D 407/04 (2013.01); C07D 409/04 (2013.01); C07D 417/14 (2013.01);
Abstract

Provided is an EP2 agonist having excellent safety. A compound represented by general formula (I) (wherein all symbols are as defined in the description), a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has an EP2 agonist activity and is highly safe, and is therefore useful as a medicine, particularly a therapeutic agent for diseases associated with EP2 receptors, such as immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases and cartilage injury.


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