The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
Jul. 09, 2018
Applicant:
Mallinckrodt Llc, Hazelwood, MO (US);
Inventor:
William McGhee, Fenton, MO (US);
Assignee:
MALLINCKRODT LLC, Hazelwood, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 33/24 (2019.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1277 (2013.01); A61K 9/127 (2013.01); A61K 9/1272 (2013.01); A61K 33/24 (2013.01);
Abstract
The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1. Methods for the preparation of liposomal cisplatin and the treatment of cancer are also disclosed.