The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
May. 05, 2016
Applicant:
Revivicor, Inc., Blacksburg, VA (US);
Inventor:
David L. Ayares, Blacksburg, VA (US);
Assignee:
Revivicor, Inc., Blacksburg, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/00 (2006.01); A01K 67/033 (2006.01); A01K 67/027 (2006.01); A61K 35/39 (2015.01); C12N 15/85 (2006.01); C12N 9/10 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0276 (2013.01); A01K 67/0278 (2013.01); A61K 35/39 (2013.01); C12N 9/1051 (2013.01); C12N 15/8509 (2013.01); C12Y 204/01087 (2013.01); A01K 2217/052 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2227/108 (2013.01); A01K 2267/025 (2013.01); A01K 2267/0362 (2013.01); C12N 2830/40 (2013.01);
Abstract
The present invention provides certain animals, and in particular porcine animals, tissue and cells derived from these, which lack any expression of functional alpha 1,3 galactosyltransferase (aGT) and express one or more additional transgenes which make them suitable donors for pancreatic islet xenotransplantation. Methods of treatment and prevention of diabetes using cells derived from such animals are also provided.