The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Sep. 02, 2013
Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;
Fumikazu Shinohara, Tokyo, JP;
Asana Makino, Tokyo, JP;
Junichiro Yamamoto, Tokyo, JP;
Taiji Oashi, Tokyo, JP;
Michihiko Suzuki, Tokyo, JP;
Jun-ichi Saito, Tokyo, JP;
Takahiro Nakajima, Tokyo, JP;
Tomoyuki Nishikawa, Tokyo, JP;
Masayoshi Nakoji, Tokyo, JP;
Yuichi Takahashi, Tokyo, JP;
KYOWA HAKKO KIRIN CO., LTD., Tokyo, JP;
Abstract
An oligonucleotide having improved affinity for AGO2 is disclosed. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) wherein Xis an oxygen atom or the like, Ris formula (IIA), wherein Ris halogen or the like, and Ris a hydrogen atom or the like, or formula (IVA) wherein Yis a nitrogen atom or the like, and Yis CH or the like, or the like, Ris a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and Ris a hydrogen atom or the like at the 5' end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. A method for improving the knockdown activity of an oligonucleotide wherein the oligonucleotide has a knockdown activity against an mRNA encoding a protein involved in a disease.