The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Jan. 22, 2016
Applicant:
Musc Foundation for Research Development, Charleston, SC (US);
Inventors:
Mark Rubinstein, James Island, SC (US);
David Cole, Mount Pleasant, SC (US);
Assignee:
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, Charleston, SC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61K 38/17 (2006.01); A61K 38/20 (2006.01); C07K 14/715 (2006.01); C12N 15/85 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); A61K 35/17 (2013.01); A61K 38/1793 (2013.01); A61K 38/20 (2013.01); A61K 38/2013 (2013.01); C07K 14/705 (2013.01); C07K 14/70521 (2013.01); C07K 14/715 (2013.01); C07K 14/7155 (2013.01); C12N 15/85 (2013.01); C12N 2510/00 (2013.01);
Abstract
Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.