The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
May. 14, 2018
Applicant:
Aduro Biotech Holdings, Europe B.v., Oss, NL;
Inventors:
Hans van Eenennaam, Nijmegen, NL;
Andrea van Elsas, Oss, NL;
David Lutje Hulsik, Nijmegen, NL;
Jan Paul Medema, Nieuw Vennep, NL;
Assignee:
ADURO BIOTECH HOLDINGS, EUROPE B.V., Oss, NL;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01); G01N 33/564 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2875 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); G01N 33/564 (2013.01); G01N 33/57488 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/30 (2013.01); C07K 2317/33 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); G01N 2800/24 (2013.01);
Abstract
The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the Vand Vdomains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.