The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Jul. 13, 2015
Applicant:
Merck & Cie, Schaffhausen, CH;
Inventors:
Simon Mensah Ametamey, Zurich, CH;
Rudolf Moser, Schaffhausen, CH;
Tobias Ludwig Ross, Zurich, CH;
Phoebe Lam, Zurich, CH;
Viola Groehn, Dachsen, CH;
Assignee:
MERCK & CIE, Schaffhausen, CH;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); C07D 475/04 (2006.01); A61K 51/04 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07D 475/04 (2013.01); A61K 51/0459 (2013.01); A61K 51/0497 (2013.01); C07B 59/002 (2013.01);
Abstract
The present invention is directed towards a new method of synthesis ofF-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with[F]fluoride, as well asF-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.