The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Nov. 06, 2013
Applicant:
The University of Hong Kong, Hong Kong, CN;
Inventors:
Xuechen Li, Hong Kong, CN;
Hiu Yung Lam, Hong Kong, CN;
Assignee:
The University of Hong Kong, Hong Kong, CN;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/50 (2006.01); C07C 227/18 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
C07C 227/18 (2013.01); C07K 7/08 (2013.01);
Abstract
A method for the synthesis of daptomycin or a daptomycin analog is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogs can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogs can include a different fatty acid in the side arm of the daptomycin analog.