The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Apr. 03, 2017
Applicant:
Viacyte, Inc., San Diego, CA (US);
Inventors:
Alan D. Agulnick, San Diego, CA (US);
Kevin Allen D'Amour, San Diego, CA (US);
Assignee:
ViaCyte, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/39 (2015.01); C12N 5/071 (2010.01); A61K 35/545 (2015.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 35/39 (2013.01); A61K 35/545 (2013.01); C12N 5/0676 (2013.01); C12N 5/0678 (2013.01); C12N 2500/25 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/119 (2013.01); C12N 2501/15 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/195 (2013.01); C12N 2501/385 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2501/998 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2533/90 (2013.01);
Abstract
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.