The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Apr. 10, 2018
Madrigal Pharmaceuticals, Inc., West Conshohocken, PA (US);
Hoffman-la Roche Inc., Little Falls, NJ (US);
Rebecca Taub, Villanova, PA (US);
Charles H. Reynolds, Lansdale, PA (US);
Lianhe Shu, Livingston, NJ (US);
Ping Wang, Nutley, NJ (US);
Duk Soon Choi, Flanders, NJ (US);
Madrigal Pharmaceuticals, Inc., West Conshohocken, PA (US);
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.