The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2019
Filed:
Jul. 27, 2016
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Antonella Converso, Elkins Park, PA (US);
Kevin Rodzinak, Valdosta, GA (US);
Assignee:
Merck, Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4704 (2006.01); C07D 215/227 (2006.01); A61K 31/4709 (2006.01); C07D 401/14 (2006.01); C07D 215/54 (2006.01); C07D 401/02 (2006.01); C07D 405/12 (2006.01); A61P 25/14 (2006.01); A61P 25/18 (2006.01); A61K 31/277 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/4545 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 31/277 (2013.01); A61P 25/14 (2018.01); A61P 25/18 (2018.01); C07D 215/54 (2013.01); C07D 401/02 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/4545 (2013.01); A61K 31/55 (2013.01);
Abstract
The present invention is directed to azacyanoquinolinone compounds of the general structural formula: (wherein Rand Rare defined herein) which may be useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.