The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2019
Filed:
Jul. 23, 2018
Thermo Fisher Scientific (Bremen) Gmbh, Bremen, DE;
Universiteit Maastricht, Maastricht, NL;
Universiteit Utrecht Holding B.v., Utrecht, NL;
Alexander Alekseevich Makarov, Bremen, DE;
Ronald M. A. Heeren, Maastricht, NL;
Albert J. R. Heck, Utrecht, NL;
Thermo Fisher Scientific (Bremen) GmbH, Bremen, DE;
Universiteit Maastricht, Maastricht, NL;
Universiteit Ultrecht Holding B.V., Utrecht, NL;
Abstract
A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.