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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10373700 B1

PDFFull Text
Date of Patent:
Aug. 06, 2019

Filed:

Mar. 11, 2013

Non-invasive functional assessment of coronary artery stenosis including simulation of hyperemia by changing resting microvascular resistance

Applicant:

Siemens Healthcare Gmbh, Erlangen, DE;

Inventors:

Puneet Sharma, Princeton Junction, NJ (US);

Lucian Mihai Itu, Brasov, RO;

Ali Kamen, Skillman, NJ (US);

Bogdan Georgescu, Plainsboro, NJ (US);

Xudong Zheng, Bangor, ME (US);

Huseyin Tek, Princeton, NJ (US);

Dorin Comaniciu, Princeton Junction, NJ (US);

Dominik Bernhardt, Voerstetten, DE;

Fernando Vega-Higuera, Erlangen, DE;

Michael Scheuering, Forchheim, DE;

Assignee:

Siemens Healthcare GmbH, Erlangen, DE;

Attorney:
Primary Examiner:

G Steven Vanni

Int. Cl.
CPC ...
A61B 5/02 (2006.01); A61B 5/11 (2006.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); G16B 5/00 (2019.01); G16H 50/50 (2018.01);
U.S. Cl.
CPC ...
G16B 5/00 (2019.02); A61B 5/02007 (2013.01); A61B 5/1128 (2013.01); A61B 6/032 (2013.01); A61B 6/503 (2013.01); A61B 6/5217 (2013.01); G16H 50/50 (2018.01); A61B 2576/023 (2013.01);
Abstract

A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.

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