The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2019
Filed:
Dec. 18, 2014
Friedrich-alexander Universität Erlangen-nürnberg, Erlangen, DE;
Thomas Harrer, Erlangen, DE;
Angela Hückelhoven, Berglen, DE;
Friedrich-Alexander Universität Erlangen-Nürnberg, Erlanen, DE;
Abstract
The present invention relates to specific T-cell receptor a-chains, T-cell receptor β-chains and T-cell receptors comprising said T-cell receptor a-chain and/or β-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or β-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or β-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.