The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2019
Filed:
Jul. 06, 2012
Applicants:
Martyn David Ticehurst, Kent, GB;
Ivan Marziano, Kent, GB;
Eleftherios Kougoulos, Morrisville, NC (US);
Inventors:
Martyn David Ticehurst, Kent, GB;
Ivan Marziano, Kent, GB;
Eleftherios Kougoulos, Morrisville, NC (US);
Assignee:
Pfizer Limited, Sandwich, Kent, GB;
Primary Examiner:
Int. Cl.
CPC ...
C07C 22/00 (2006.01); C07C 303/00 (2006.01); C07C 321/00 (2006.01); C07J 31/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07J 31/00 (2013.01); C07J 31/006 (2013.01); A61K 9/0075 (2013.01); C07B 2200/13 (2013.01); Y10T 428/2982 (2015.01);
Abstract
The invention relates to a novel crystallization process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronization. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallize out of the solution as crystalline form.