The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2019
Filed:
Nov. 21, 2013
Applicant:
Ptc Therapeutics, Inc., South Plainfield, NJ (US);
Inventors:
Wu Du, Cranbury, NJ (US);
Ramil Baiazitov, East Brunswick, NJ (US);
Chang-Sun Lee, Belle Mead, NJ (US);
Young-Choon Moon, Belle Mead, NJ (US);
Steven D. Paget, Hillsborough, NJ (US);
Hongyu Ren, Dayton, NJ (US);
Nadiya Sydorenko, Princeton, NJ (US);
Richard Gerald Wilde, Somerville, NJ (US);
Assignee:
PTC Therapeutics, Inc., South Plainfield, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 31/506 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01);
Abstract
Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.