The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 06, 2019

Filed:

May. 30, 2017
Applicant:

The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Washington, DC (US);

Inventors:

Juan Jose Marugan, Gaithersburg, MD (US);

Wei Zheng, Potomac, MD (US);

Jingbo Xiao, Rockville, MD (US);

John McKew, Poolesville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/16 (2006.01); A61K 31/355 (2006.01); C07D 311/58 (2006.01); A61K 31/335 (2006.01); A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); C07D 311/72 (2006.01); A61K 31/122 (2006.01); A61K 31/724 (2006.01); C07C 50/02 (2006.01); C07C 50/06 (2006.01); C07C 50/24 (2006.01);
U.S. Cl.
CPC ...
C07D 311/58 (2013.01); A61K 31/122 (2013.01); A61K 31/335 (2013.01); A61K 31/35 (2013.01); A61K 31/352 (2013.01); A61K 31/353 (2013.01); A61K 31/355 (2013.01); A61K 31/724 (2013.01); C07C 50/02 (2013.01); C07C 50/06 (2013.01); C07C 50/24 (2013.01); C07D 311/72 (2013.01);
Abstract

The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorder, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.


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