The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2019
Filed:
Mar. 14, 2013
Applicant:
Vascular Biogenics Ltd., Or Yehuda, IL;
Inventors:
Yael Cohen, Kiryat-Ono, IL;
Livnat Bangio, Petach-Tikva, IL;
Andrew J. Brenner, Boerne, TX (US);
Eyal Breitbart, Hashmonaim, IL;
Assignee:
Vascular Biogenics Ltd., Or Yehuda, IL;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 38/17 (2006.01); A61K 38/16 (2006.01); C07K 14/705 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61N 5/10 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/177 (2013.01); A61K 38/162 (2013.01); A61K 39/39558 (2013.01); A61K 48/005 (2013.01); A61N 5/1001 (2013.01); A61N 5/1077 (2013.01); C07K 14/70578 (2013.01); A61K 2039/5258 (2013.01); A61N 2005/1087 (2013.01); C12N 2799/022 (2013.01); Y02E 60/36 (2013.01);
Abstract
Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.