The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 06, 2019

Filed:

Nov. 12, 2013
Applicant:

Regenerative Research Foundation, Rensselaer, NY (US);

Inventors:

Sally Temple Stern, Slingerlands, NY (US);

Natalia Lowry, Albany, NY (US);

Jeffrey Stern, Slingerlands, NY (US);

Susan K. Goderie, Ballston Spa, NY (US);

Assignee:

Regenerative Research Foundation, Rensselaer, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/30 (2015.01); A61K 38/18 (2006.01); A61K 9/19 (2006.01); A61K 38/17 (2006.01); A61K 9/00 (2006.01); C12N 5/0797 (2010.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 35/30 (2013.01); A61K 38/18 (2013.01); C12N 5/0623 (2013.01);
Abstract

The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention relates to the use of biodegradable microspheres to deliver exogenous factors, such as the morphogenic factor, sonic hedgehog (Shh), to the site of spinal cord injury. In certain embodiments, the Shh-releasing microspheres are administered together with stem cells, which may be spinal cord neural stem cells. In certain embodiments, the invention relates to regrowth of neural cells in both the central and peripheral nervous systems.


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