The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2019
Filed:
Aug. 25, 2014
The Catholic University of Korea Industry—academic Cooperation Foundation, Seoul, KR;
Mi-La Cho, Seoul, KR;
Chul-Woo Yang, Seoul, KR;
Dong-Yun Shin, Seoul, KR;
Min-Jung Park, Incheon, KR;
Seon-Yeong Lee, Suwon-si, KR;
Sung-Hee Lee, Seoul, KR;
Eun-Ji Yang, Seoul, KR;
Hye-Jin Son, Seoul, KR;
Eun-Kyung Kim, Seoul, KR;
Jae-Kyung Kim, Cheonan-si, KR;
Abstract
The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.