The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 06, 2019

Filed:

Feb. 12, 2016
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

Hyun Koo, Philadelphia, PA (US);

Lizeng Gao, Philadelphia, PA (US);

David Cormode, Philadelphia, PA (US);

Pratap Naha, Philadelphia, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 8/19 (2006.01); A01N 59/16 (2006.01); A61K 33/26 (2006.01); A61K 33/40 (2006.01); A61Q 11/00 (2006.01); A61K 9/14 (2006.01); A61K 9/51 (2006.01); A61K 47/69 (2017.01); A61K 8/02 (2006.01); A61K 8/20 (2006.01); A61K 8/22 (2006.01); A61K 8/66 (2006.01); A61K 8/73 (2006.01); A61K 8/24 (2006.01); A61K 8/21 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 8/19 (2013.01); A01N 59/16 (2013.01); A61K 8/0245 (2013.01); A61K 8/20 (2013.01); A61K 8/21 (2013.01); A61K 8/22 (2013.01); A61K 8/24 (2013.01); A61K 8/66 (2013.01); A61K 8/73 (2013.01); A61K 9/14 (2013.01); A61K 9/5161 (2013.01); A61K 33/26 (2013.01); A61K 33/40 (2013.01); A61K 47/6923 (2017.08); A61Q 11/00 (2013.01); A61K 9/006 (2013.01); A61K 9/0063 (2013.01); A61K 2800/413 (2013.01); A61K 2800/624 (2013.01); A61K 2800/882 (2013.01); A61K 2800/92 (2013.01); Y02A 50/471 (2018.01); Y02A 50/473 (2018.01);
Abstract

The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.


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