The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2019
Filed:
Feb. 18, 2016
Applicant:
U3 Pharma Gmbh, Martinsried, DE;
Inventors:
Mike Rothe, Krailling, DE;
Martin Treder, Martinsried, DE;
Assignee:
Daiichi Sankyo Europe GmbH, Munich, DE;
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); A61K 39/395 (2006.01); G01N 33/53 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5748 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); G01N 33/574 (2013.01); G01N 33/57407 (2013.01); G01N 33/57492 (2013.01); A61K 39/395 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); G01N 2333/71 (2013.01); G01N 2333/91205 (2013.01); G01N 2440/14 (2013.01); G01N 2800/205 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present invention provides methods for the determination of the activation level of Receptor Tyrosine kinases, e.g. phosporylated HER3, for the selection of patients for disease treatment. Methods are also provided for the evaluation of the biological and pharmacodynamic effects of an active substance and/or its efficacy in disease treatment, utilizing a tissue sample from a test subject, for example tumor material or normal tissue such as skin or hair follicle. Further, methods for the treatment of HER receptor-associated diseases are disclosed.