The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 30, 2019

Filed:

Nov. 13, 2015
Applicants:

The Regents of the University of California, Oakland, CA (US);

Ionis Pharmaceuticals, Inc., Calrsbad, CA (US);

Inventors:

Aldons J. Lusis, Tarzana, CA (US);

Brian Parks, Los Angeles, CA (US);

Richard Lee, Oceanside, CA (US);

Assignees:
Attorney:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 9/10 (2006.01); A61K 31/397 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/397 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); C12N 9/1029 (2013.01); C12Y 203/01051 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/341 (2013.01); C12N 2320/31 (2013.01);
Abstract

Provided herein are methods, compounds, and compositions for reducing expression of an AGPAT5 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids, insulin resistance and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cardiometabolic disease, disorder or condition, or a physiological marker thereof, in an individual in need.


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