The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2019
Filed:
Jul. 06, 2016
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Petra Rueger, Penzberg, DE;
Georg Tiefenthaler, Sindelsdorf, DE;
Ekkehard Moessner, Kreuzlingen, CH;
Jens Niewoehner, Munich, DE;
Adrian Hugenmatter, Zurich, CH;
Cuiying Shao, Shanghai, CN;
Francesca Ros, Bernried, DE;
Gang Xu, Shanghai, CN;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
Herein is reported a blood brain barrier shuttle module comprising a brain effector entity, a linker and one monovalent binding entity which binds to a blood brain barrier receptor, wherein the linker couples the effector entity to the monovalent binding entity which binds to the blood brain barrier receptor wherein the monovalent binding entity does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03).