The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2019
Filed:
May. 24, 2017
Applicant:
Ohio University, Athens, OH (US);
Inventor:
Rathindra N. Bose, Athens, OH (US);
Assignee:
Ohio University, Athens, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 15/00 (2006.01); A61K 31/555 (2006.01); A61K 33/24 (2019.01);
U.S. Cl.
CPC ...
C07F 15/0093 (2013.01); A61K 31/555 (2013.01); A61K 33/24 (2013.01);
Abstract
Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed.