The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2019
Filed:
Jan. 21, 2015
Applicants:
The Johns Hopkins University, Baltimore, MD (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Inventors:
Assignees:
UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/706 (2006.01); A61K 31/4184 (2006.01); A61K 31/7068 (2006.01); A61K 31/145 (2006.01); A61K 31/166 (2006.01); A61K 31/496 (2006.01); A61K 31/502 (2006.01); A61K 31/55 (2006.01); A61K 31/5025 (2006.01);
U.S. Cl.
CPC ...
A61K 31/706 (2013.01); A61K 31/145 (2013.01); A61K 31/166 (2013.01); A61K 31/4184 (2013.01); A61K 31/496 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); A61K 31/55 (2013.01); A61K 31/7068 (2013.01);
Abstract
The presently disclosed subject matter provides methods to treat cancer cells using low doses of DNA demethylating agents and poly ADP ribose polymerase (PARP) inhibitors. Methods also are provided for sensitizing a cell to a PARP inhibitor.