The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 30, 2019

Filed:

Aug. 12, 2016
Applicant:

North Carolina State University, Raleigh, NC (US);

Inventors:

Zhen Gu, Apex, NC (US);

Quanyin Hu, Raleigh, NC (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 31/337 (2006.01); A61K 31/4745 (2006.01); A61K 31/513 (2006.01); A61K 47/68 (2017.01); A61K 9/00 (2006.01); A61K 31/351 (2006.01); A61K 31/437 (2006.01); A61K 31/505 (2006.01); A61K 33/24 (2019.01);
U.S. Cl.
CPC ...
A61K 9/5068 (2013.01); A61K 31/337 (2013.01); A61K 31/4745 (2013.01); A61K 31/513 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 9/0019 (2013.01); A61K 31/351 (2013.01); A61K 31/437 (2013.01); A61K 31/505 (2013.01); A61K 33/24 (2013.01); A61K 47/6803 (2017.08); A61K 2300/00 (2013.01); Y10S 977/773 (2013.01); Y10S 977/906 (2013.01);
Abstract

Disclosed herein is a platelet membrane-coated nanovehicle having an inner core comprising a drug delivery matrix, and an outer shell platelet membrane coating the inner core. The inner core can be any drug delivery matrix capable of delivering a therapeutic agent to a cell. The outer shell platelet membrane can be a natural or synthetic membrane comprising platelet proteins capable of interacting with cancer cells. Also disclosed is a method for treating cancer in a subject that involves administering to the subject a platelet membrane-coated nanovehicle disclosed herein. Also disclosed is a method for treating vascular disease in a subject that involves administering to the subject a platelet membrane-coated nanovehicle disclosed herein.


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