The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2019
Filed:
Mar. 01, 2018
Waters Technologies Corporation, Milford, MA (US);
Michael O. Fogwill, South Grafton, MA (US);
Joshua A. Shreve, Franklin, MA (US);
Michael Eggertson, Natick, MA (US);
Thomas S. McDonald, Littleton, MA (US);
Joseph D. Michienzi, Plainville, MA (US);
Abhijit Tarafder, Franklin, MA (US);
Waters Technologies Corporation, Milford, MA (US);
Abstract
The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO-based chromatography system. A first pressure control element is located downstream of a CO-based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.