The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2019
Filed:
Jan. 06, 2017
Applicant:
Boston Medical Center Corporation, Boston, MA (US);
Inventors:
Weining Lu, West Roxbury, MA (US);
Xueping Fan, Braintree, MA (US);
David J. Salant, Newton, MA (US);
Assignee:
BOSTON MEDICAL CENTER CORPORATION, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61P 13/12 (2006.01); A61P 13/02 (2006.01); C12Q 1/6883 (2018.01); G01N 33/68 (2006.01); A61K 45/06 (2006.01); C07K 14/705 (2006.01); A61K 31/7088 (2006.01); A61K 31/713 (2006.01); A61K 39/395 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); G16H 50/30 (2018.01); G06F 19/20 (2011.01); G06F 19/00 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 38/177 (2013.01); A61K 38/1709 (2013.01); A61K 38/1774 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 13/02 (2018.01); A61P 13/12 (2018.01); C07K 14/47 (2013.01); C07K 14/70503 (2013.01); C07K 16/18 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); G01N 33/6893 (2013.01); G06F 19/00 (2013.01); G06F 19/20 (2013.01); G06F 19/3456 (2013.01); G16H 50/30 (2018.01); C07K 2317/24 (2013.01); C07K 2319/70 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/70503 (2013.01); G01N 2800/347 (2013.01); Y02A 90/24 (2018.01); Y02A 90/26 (2018.01);
Abstract
Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.