The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2019
Filed:
Mar. 08, 2018
Medizinische Universität Wien, Vienna, AT;
Johannes Hofer, Vienna, AT;
Peter Steinberger, Vienna, AT;
Gerhard Zlabinger, Vienna, AT;
Georg Böhmig, Vienna, AT;
Florian Forster, Ösmo, SE;
Judith Leitner, Vienna, AT;
Markus Wahrmann, Vienna, AT;
Margarethe Merio, Vienna, AT;
Johannes Kovarik, Vienna, AT;
Markus Hölzl, New York, NY (US);
David E. Isenman, Toronto, CA;
Medizinische Universität Wien, Vienna, AT;
Abstract
The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methods Also antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.