The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 23, 2019

Filed:

Aug. 20, 2018
Applicants:

Brandeis University, Waltham, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Seth Fraden, Newton, MA (US);

Hakim Boukellal, Paris, FR;

Yanwei Jia, Medford, MA (US);

Seila Selimovic, Bronx, NY (US);

Amy Rowat, Cambridge, MA (US);

Jeremy Agresti, Cambridge, MA (US);

David A. Weitz, Cambridge, MA (US);

Assignees:

President and Fellows of Harvard College, Cambridge, MA (US);

Brandeis University, Waltham, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
F17D 1/12 (2006.01); G01N 1/38 (2006.01); B01L 3/00 (2006.01); G01N 15/02 (2006.01); G01N 15/14 (2006.01); G01N 1/28 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502784 (2013.01); B01L 3/502746 (2013.01); F17D 1/12 (2013.01); G01N 1/28 (2013.01); G01N 15/0272 (2013.01); G01N 15/1484 (2013.01); B01L 2200/0673 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0877 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0688 (2013.01); B01L 2400/0694 (2013.01); B01L 2400/082 (2013.01); G01N 2015/0092 (2013.01); Y10T 137/0324 (2015.04); Y10T 137/0391 (2015.04); Y10T 137/0396 (2015.04); Y10T 137/2082 (2015.04); Y10T 137/218 (2015.04); Y10T 436/2575 (2015.01);
Abstract

Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.


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