The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10357554 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 23, 2019

Filed:

Nov. 11, 2014
Applicant:

The United States of America, As Represented BY the Secretary of the Army, Washington, DC (US);

Inventors:

Sheetij Dutta, Silver Spring, MD (US);

Adrian Batchelor, Hinckley, OH (US);

Michael Foley, Fort Detrick, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 39/015 (2006.01); C07K 16/20 (2006.01); C07K 14/445 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/015 (2013.01); C07K 14/445 (2013.01); C07K 16/205 (2013.01); A61K 38/00 (2013.01); A61K 2039/55566 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); Y02A 50/412 (2018.01); Y02A 50/58 (2018.01);
Abstract

Disclosed are AMA-1 immunogenic peptides and epitopes, nucleotide sequences encoding the peptides and epitopes, compositions, and vaccines including the peptides and/or epitopes. Antibodies that specifically bind to AMA-1 and the AMA-1 epitopes and immunogenic peptides disclosed herein are also provided. The disclosure provides for expression vectors, host cells, and methods for making the polypeptides and antibodies. Also provided are methods of treatment, prevention, vaccination, and/or immunization of a subject against malaria and the clinical indications associated with malaria.


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