The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 23, 2019

Filed:

Oct. 10, 2017
Applicants:

Board of Regents, the University of Texas System, Austin, TX (US);

University of Cincinnati, Cincinnati, OH (US);

Inventors:

Susan T. Laing, Houston, TX (US);

Shaoling Huang, Houston, TX (US);

David D. McPherson, Houston, TX (US);

Christy K. Holland, Cincinnati, OH (US);

Melvin E. Klegerman, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 47/69 (2017.01); A61K 49/22 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0009 (2013.01); A61K 9/127 (2013.01); A61K 47/6911 (2017.08); A61K 47/6913 (2017.08); A61K 49/227 (2013.01);
Abstract

We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.


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