The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 16, 2019

Filed:

May. 31, 2016
Applicants:

Cedars-sinai Medical Center, Los Angeles, CA (US);

The John Hopkins University, Baltimore, MD (US);

Inventors:

Eric Grote, Beverly Hills, CA (US);

Qin Fu, Beverly Hills, CA (US);

Jennifer Van Eyk, Los Angeles, CA (US);

Vidya Venkatraman, Los Angeles, CA (US);

Assignees:

Cedars-Sinai Medical Center, Los Angeles, CA (US);

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); G16B 30/00 (2019.01); G16B 40/00 (2019.01); G16B 99/00 (2019.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); C12Q 1/68 (2013.01); G01N 33/53 (2013.01); G01N 33/6827 (2013.01); G16B 30/00 (2019.02); G16B 40/00 (2019.02); G16B 99/00 (2019.02);
Abstract

Described herein are methods for identifying signature peptides for quantifying a polypeptide of interest in a sample. The methods include cleaving the polypeptide into peptides; detecting a multiplicity of the peptides with a quantitative analytical instrument; comparing the linearity of signals attributable to pairs of the peptides in a multiplicity of samples; and selecting signature peptides from a group of peptides with more highly correlated signals.


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