The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Apr. 24, 2016
Technion Research & Development Foundation Limited, Haifa, IL;
Ramot AT Tel-aviv University Ltd., Tel-Aviv, IL;
Walter Gabriel Wasser, Jerusalem, IL;
Rambam Med-tech Ltd., Haifa, IL;
Karl Skorecki, Haifa, IL;
Shay Tzur, Haifa, IL;
Saharon Rosset, Ramot-HaShavim, IL;
Walter Gabriel Wasser, Jerusalem, IL;
Doron M. Behar, Hof HaCarmel, IL;
Revital Shemer, Haifa, IL;
Technion Research & Development Foundation Limited, Haifa, IL;
Ramot at Tel-Aviv University Ltd., Tel-Aviv, IL;
Walter Gabriel WASSER, Jerusalem, IL;
Rambam Med-Tech Ltd., Haifa, IL;
Abstract
Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity onas compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on theunder identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.