The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 16, 2019

Filed:

Feb. 25, 2017
Applicant:

Complete Genomics, Inc., Mountain View, CA (US);

Inventors:

Radoje Drmanac, Los Altos Hills, CA (US);

Matthew J. Callow, Mountain View, CA (US);

Snezana Drmanac, Los Altos Hills, CA (US);

Brian K. Hauser, Campbell, CA (US);

George Yeung, Mountain View, CA (US);

Assignee:

Complete Genomics, Inc., San Jose, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6874 (2018.01); C12Q 1/682 (2018.01); C12Q 1/6837 (2018.01); C12Q 1/6869 (2018.01); C07H 21/04 (2006.01); C07K 1/04 (2006.01); G01N 15/14 (2006.01); C12Q 1/6806 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6874 (2013.01); C07H 21/04 (2013.01); C07K 1/047 (2013.01); C12Q 1/682 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6837 (2013.01); C12Q 1/6869 (2013.01); G01N 15/1404 (2013.01); G01N 15/1434 (2013.01); C12Q 2525/151 (2013.01); C12Q 2525/313 (2013.01); C12Q 2531/125 (2013.01); C12Q 2565/513 (2013.01); Y10S 977/778 (2013.01); Y10S 977/789 (2013.01); Y10S 977/792 (2013.01); Y10S 977/88 (2013.01); Y10S 977/882 (2013.01);
Abstract

The invention relates to an automated method for high-throughput DNA sequencing from high density DNA arrays by (a) initiating a first sequencing reaction on a first high density DNA array; and imaging said first high density DNA array using a detector, and (b) initiating a first sequencing reaction on a second high density DNA array; and imaging said second high density DNA array using the detector, wherein the first sequencing reaction in (a) is initiated before the first sequencing reaction in (b) is initiated such that the sequencing reactions in (a) and (b) are staggered. By using asynchronous sequencing reactions and imaging two separate arrays using one detector, imaging can be carried out on one array while sequencing reactions are carried out on one the other, substrate, the other substrate is imaged, reducing the idle time of the imaging system.


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