The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
May. 27, 2016
Stichting Het Nederlands Kanker Instituut-antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, NL;
Thijn Reinout Brummelkamp, Amsterdam, NL;
Joppe Daniël Maria Nieuwenhuis, Amsterdam, NL;
Lucas Tilmann Jae, Amsterdam, NL;
Markus Brockmann, Amsterdam, NL;
Vincent Arthur Blomen, Amsterdam, NL;
Matthijs Raaben, Amsterdam, NL;
Abstract
The present invention comprises generally applicable methods for identifying endogenous physiologically relevant genetic elements that affects a intracellular phenotype of interest. In the methods, non-living cells that have been subjected to a mutagenesis treatment are sorted based on phenotype and analyzed to identify the genetic element. By use of these methods, elements previously unknown to be involved in a phenotype can be identified, for example in relationship to health conditions, external stress or drug response, in particular in cancer.