The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Sep. 05, 2017
Mainline Biosciences, Malvern, PA (US);
Junge Zhang, Malvern, PA (US);
Liang Zeng Yan, Carmel, IN (US);
Mainline Biosciences, Malvern, PA (US);
Abstract
The present invention provides compounds that are antagonists of CXCR4 and methods for using the same for treatment of a clinical condition associated with CXCR4 activation. In particular, compounds of the invention include cyclic peptides. Compounds of the invention can be used to treat a variety of clinical conditions, including but not limited to, cancers, pulmonary fibrosis, HIV infection, rheumatoid arthritis, and other immune disorders. In addition, compounds of the invention can also be used in stem cell therapy. In one particular embodiment, compounds of the invention are cyclic peptides of the formula: or a pharmaceutically acceptable salt thereof, wherein a is 0 or 1; AAalong with the sulfur atom that is attached thereto is 3-mercaptopropionic acid, optionally substituted cysteine, or optionally substituted homocysteine; AAalong with the sulfur atom that is attached thereto is cysteine or homocysteine; Aris an optionally substituted aryl; Xis Arg, Dap, Dab, Orn, Lys, Dap(iPr), Dab(iPr), Orn(iPr), or Lys(iPr); Xis Arg, Dap, Dab, Orn, Lys, Dap(iPr), Dab(iPr), Orn(iPr), Lys(iPr), a D-isomer thereof, or absent; Xis Gly or absent; Xis Phe, 2Nal, 1Nal, or absent; Xis Gly or absent; Ris —ORor —NHR; Ris H or alkyl; and Ris H, alkyl, optionally substituted aryl, optionally substituted aralkyl.