IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10351575 B1

PDFFull Text
Date of Patent:
Jul. 16, 2019

Filed:

Nov. 13, 2013

Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain

Applicant:

Array Biopharma Inc., Boulder, CO (US);

Inventors:

Shelley Allen, Boulder, CO (US);

Steven Wade Andrews, Boulder, CO (US);

James F. Blake, Boulder, CO (US);

Barbara J. Brandhuber, Boulder, CO (US);

Julia Haas, Boulder, CO (US);

Yutong Jiang, Boulder, CO (US);

Timothy Kercher, San Diego, CA (US);

Gabrielle R. Kolakowski, Boulder, CO (US);

Allen A. Thomas, Kearney, NE (US);

Shannon L. Winski, Boulder, CO (US);

Assignee:

Array BioPharma Inc., Boulder, CO (US);

Attorneys:

Viksnins Harris Padys Malen LLP

Sarah S. Mastous

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 491/048 (2006.01); C07D 405/14 (2006.01); C07D 231/40 (2006.01); C07D 231/54 (2006.01); C07D 401/12 (2006.01); C07D 403/02 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 453/02 (2006.01); C07D 231/52 (2006.01); C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 409/14 (2006.01); C07D 471/08 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); C07D 231/40 (2013.01); C07D 231/52 (2013.01); C07D 231/54 (2013.01); C07D 231/56 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/02 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01);
Abstract

Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

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