The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Apr. 14, 2016
Applicant:
Beigene, Ltd., Camana Bay, Grand Cayman, KY;
Inventors:
Guoliang Zhang, Beijing, CN;
Changyou Zhou, Princeton, NJ (US);
Assignee:
BEIGENE, LTD., Grand Cayman, KY;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); C07D 471/04 (2006.01); C07D 405/14 (2006.01); A61K 31/4355 (2006.01); C07C 51/43 (2006.01); C07C 57/145 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 35/00 (2018.01); C07C 51/43 (2013.01); C07C 57/145 (2013.01); C07B 2200/13 (2013.01);
Abstract
The invention relates to 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo [d] imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa [b] benzofuran-5-yl) oxy)-3,4-dihydro-1, 8-naphthyridin-2 (1H)-one (Compound 1) maleate salts, in particular the sesqui-maleate salt and its crystalline forms, methods of preparation, pharmaceutical compositions, and therapeutic uses for treatment of diseases or disorders mediated by BRAF or other kinases.