The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Sep. 18, 2015
Oxford University Innovation Limited, Oxford, GB;
Jürgen Brem, Oxford, GB;
Sander S. Van Berkel, Oxford, GB;
Michael A. McDonough, Oxford, GB;
Christopher J. Schofield, Oxford, GB;
Oxford University Innovation Limited, Botley, Oxford, GB;
Abstract
A compound which is a thienolate of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R, R, Ring A1, n and Ring A2 are as defined herein, are found to be useful in inhibiting metallo-beta-lactamase and therefore in potentiating the activity of beta lactamase antibiotics. The compound can be used alone or in combination with a rhodanine of formula (II) or a pharmaceutically acceptable salt thereof: (II) wherein R, Ring A1, n, Ring A2, L and Ring B are as defined herein. Treatment or prevention of bacterial infection in combination with beta-lactam antibiotic agents is also provided.