The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 16, 2019

Filed:

Feb. 16, 2016
Applicant:

B. G. Negev Technologies and Applications Ltd., AT Ben-gurion University, Beer Sheva, IL;

Inventors:

Doron Pappo, Lehavim, IL;

Regev Parnes, Beer Sheva, IL;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 15/04 (2006.01); C07C 319/18 (2006.01); C07C 321/20 (2006.01); C07B 31/00 (2006.01); C07B 37/04 (2006.01); C07B 45/06 (2006.01); A61K 31/015 (2006.01); A61K 31/10 (2006.01); A61K 31/335 (2006.01); A61K 31/565 (2006.01); C07C 317/14 (2006.01); C07C 327/06 (2006.01); C07C 253/30 (2006.01); C07C 39/14 (2006.01); C07C 39/38 (2006.01); C07C 43/225 (2006.01); C07C 43/23 (2006.01); C07J 1/00 (2006.01); C07J 31/00 (2006.01); C07D 317/64 (2006.01); C07D 209/10 (2006.01); A61K 31/47 (2006.01); C07C 323/16 (2006.01); C07C 323/56 (2006.01); C07C 323/60 (2006.01); C07C 319/14 (2006.01); C07C 323/63 (2006.01);
U.S. Cl.
CPC ...
C07C 15/04 (2013.01); A61K 31/015 (2013.01); A61K 31/10 (2013.01); A61K 31/335 (2013.01); A61K 31/47 (2013.01); A61K 31/565 (2013.01); C07B 31/00 (2013.01); C07B 37/04 (2013.01); C07B 45/06 (2013.01); C07C 39/14 (2013.01); C07C 39/38 (2013.01); C07C 43/225 (2013.01); C07C 43/23 (2013.01); C07C 253/30 (2013.01); C07C 317/14 (2013.01); C07C 319/14 (2013.01); C07C 319/18 (2013.01); C07C 321/20 (2013.01); C07C 323/16 (2013.01); C07C 323/56 (2013.01); C07C 323/60 (2013.01); C07C 323/63 (2013.01); C07C 327/06 (2013.01); C07D 209/10 (2013.01); C07D 317/64 (2013.01); C07J 1/007 (2013.01); C07J 31/006 (2013.01); C07B 2200/05 (2013.01);
Abstract

Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.


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